Parasite biomass-related inflammation, endothelial activation, microvascular dysfunction and disease severity in vivax malaria.

Plasmodium vivax can cause severe malaria, however its pathogenesis is poorly understood. In contrast to P. falciparum, circulating vivax parasitemia is low, with minimal apparent sequestration in endothelium-lined microvasculature, and pathogenesis thought unrelated to parasite biomass. However, th...

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Bibliographic Details
Main Authors: Bridget E Barber, Timothy William, Matthew J Grigg, Uma Parameswaran, Kim A Piera, Ric N Price, Tsin W Yeo, Nicholas M Anstey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004558
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