lncRNA Ubr5 promotes BMSCs apoptosis and inhibits their proliferation and osteogenic differentiation in weightless bone loss

lncRNA Ubr5 promotes BMSCs apoptosis and inhibits their proliferation and osteogenic differentiation in weightless bone loss

BackgroundWeightless bone loss is a common pathological phenomenon in weightless environments, yet its specific molecular mechanism remain incompletely elucidated. The aim of this study was to systematically investigate the differential expression profiles of mRNAs and long noncoding RNAs (lncRNAs)...

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Main Authors: Dong Wang, Yuan Gao, Yingjun Tan, Na Li, Xi Li, Jiaxiang Li, Yikai Pan, Xingcheng Zhao, Ming Yan, Yongchun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
weightless bone loss
lncRNA-mRNA coexpression network
simulated weightlessness
bone marrow mesenchymal stem cells
lncRNA Ubr5
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1543929/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1543929/full

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