Hybridization of SMILES and chemical-environment-aware tokens to improve performance of molecular structure generation

Abstract The Simplified Molecular Input Line Entry System (SMILES) is one of the most widely adopted molecular representations. However, SMILES notation suffers from limited token diversity and a lack of chemical information within individual tokens. To address these limitations while maintaining it...

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Bibliographic Details
Main Authors: Herim Han, Min Sun Yeom, Sunghwan Choi
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-01890-7
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