Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling

Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling

Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is required and sufficient to bias multipotent retinal progenitor...

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Bibliographic Details
Main Authors: Joseph Hanna, Yacine Touahri, Alissa Pak, Lauren Belfiore, Edwin van Oosten, Luke Ajay David, Sisu Han, Yaroslav Ilnytskyy, Igor Kovalchuk, Deborah Kurrasch, Satoshi Okawa, Antonio del Sol, Robert A Screaton, Isabelle Aubert, Carol Schuurmans
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-06-01
Series:eLife
Subjects:
Pten
retinal progenitor cells
glycolysis
intracellular pH
photoreceptor differentiation
Wnt signaling
Online Access:https://elifesciences.org/articles/100604
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https://elifesciences.org/articles/100604

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