Sustained and specific multiplexed immune checkpoint modulation in CAR T cells induced by targeted epigenome editing

Sustained and specific multiplexed immune checkpoint modulation in CAR T cells induced by targeted epigenome editing

Engineered T cells equipped with a chimeric antigen receptor (CAR) have shown tremendous clinical success, but tumor-mediated stimulation of T cell inhibitory receptors leads to exhaustion, hampering durable remission in patients. Mitigation of this effect via checkpoint inhibition or genome editing...

Full description

Saved in:
Bibliographic Details
Main Authors: Maria Silvia Roman Azcona, Gianni Monaco, Melissa Whitehead, Masako Monika Kaufmann, Jamal Alzubi, Toni Cathomen, Claudio Mussolino
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
epigenome editing
immunotherapy
CAR T cells
immune checkpoints
prostate cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125001726
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2162253125001726

Similar Items