Porous Biodegradable Metals for Hard Tissue Scaffolds: A Review
Scaffolds have been utilized in tissue regeneration to facilitate the formation and maturation of new tissues or organs where a balance between temporary mechanical support and mass transport (degradation and cell growth) is ideally achieved. Polymers have been widely chosen as tissue scaffolding ma...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2012/641430 |
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| author | A. H. Yusop A. A. Bakir N. A. Shaharom M. R. Abdul Kadir H. Hermawan |
| author_facet | A. H. Yusop A. A. Bakir N. A. Shaharom M. R. Abdul Kadir H. Hermawan |
| author_sort | A. H. Yusop |
| collection | DOAJ |
| description | Scaffolds have been utilized in tissue regeneration to facilitate the formation and maturation of new tissues or organs where a balance between temporary mechanical support and mass transport (degradation and cell growth) is ideally achieved. Polymers have been widely chosen as tissue scaffolding material having a good combination of biodegradability, biocompatibility, and porous structure. Metals that can degrade in physiological environment, namely, biodegradable metals, are proposed as potential materials for hard tissue scaffolding where biodegradable polymers are often considered as having poor mechanical properties. Biodegradable metal scaffolds have showed interesting mechanical property that was close to that of human bone with tailored degradation behaviour. The current promising fabrication technique for making scaffolds, such as computation-aided solid free-form method, can be easily applied to metals. With further optimization in topologically ordered porosity design exploiting material property and fabrication technique, porous biodegradable metals could be the potential materials for making hard tissue scaffolds. |
| format | Article |
| id | doaj-art-a9a595dff3d6496d84ebc07f670e77be |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-a9a595dff3d6496d84ebc07f670e77be2025-02-03T01:27:28ZengWileyInternational Journal of Biomaterials1687-87871687-87952012-01-01201210.1155/2012/641430641430Porous Biodegradable Metals for Hard Tissue Scaffolds: A ReviewA. H. Yusop0A. A. Bakir1N. A. Shaharom2M. R. Abdul Kadir3H. Hermawan4Medical Implant Technology Group (MediTeg), Faculty of Health Science and Biomedical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, MalaysiaMedical Implant Technology Group (MediTeg), Faculty of Health Science and Biomedical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, MalaysiaMedical Implant Technology Group (MediTeg), Faculty of Health Science and Biomedical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, MalaysiaMedical Implant Technology Group (MediTeg), Faculty of Health Science and Biomedical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, MalaysiaMedical Implant Technology Group (MediTeg), Faculty of Health Science and Biomedical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, MalaysiaScaffolds have been utilized in tissue regeneration to facilitate the formation and maturation of new tissues or organs where a balance between temporary mechanical support and mass transport (degradation and cell growth) is ideally achieved. Polymers have been widely chosen as tissue scaffolding material having a good combination of biodegradability, biocompatibility, and porous structure. Metals that can degrade in physiological environment, namely, biodegradable metals, are proposed as potential materials for hard tissue scaffolding where biodegradable polymers are often considered as having poor mechanical properties. Biodegradable metal scaffolds have showed interesting mechanical property that was close to that of human bone with tailored degradation behaviour. The current promising fabrication technique for making scaffolds, such as computation-aided solid free-form method, can be easily applied to metals. With further optimization in topologically ordered porosity design exploiting material property and fabrication technique, porous biodegradable metals could be the potential materials for making hard tissue scaffolds.http://dx.doi.org/10.1155/2012/641430 |
| spellingShingle | A. H. Yusop A. A. Bakir N. A. Shaharom M. R. Abdul Kadir H. Hermawan Porous Biodegradable Metals for Hard Tissue Scaffolds: A Review International Journal of Biomaterials |
| title | Porous Biodegradable Metals for Hard Tissue Scaffolds: A Review |
| title_full | Porous Biodegradable Metals for Hard Tissue Scaffolds: A Review |
| title_fullStr | Porous Biodegradable Metals for Hard Tissue Scaffolds: A Review |
| title_full_unstemmed | Porous Biodegradable Metals for Hard Tissue Scaffolds: A Review |
| title_short | Porous Biodegradable Metals for Hard Tissue Scaffolds: A Review |
| title_sort | porous biodegradable metals for hard tissue scaffolds a review |
| url | http://dx.doi.org/10.1155/2012/641430 |
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