Electron tomography and simulation of baculovirus actin comet tails support a tethered filament model of pathogen propulsion.

Electron tomography and simulation of baculovirus actin comet tails support a tethered filament model of pathogen propulsion.

Several pathogens induce propulsive actin comet tails in cells they invade to disseminate their infection. They achieve this by recruiting factors for actin nucleation, the Arp2/3 complex, and polymerization regulators from the host cytoplasm. Owing to limited information on the structural organizat...

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Main Authors: Jan Mueller, Julia Pfanzelter, Christoph Winkler, Akihiro Narita, Christophe Le Clainche, Maria Nemethova, Marie-France Carlier, Yuichiro Maeda, Matthew D Welch, Taro Ohkawa, Christian Schmeiser, Guenter P Resch, J Victor Small
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1001765
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https://doi.org/10.1371/journal.pbio.1001765

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