Discovery of potent anti-toxoplasmosis drugs from secondary metabolites in Citrus limon (lemon) leaves, supported in-silico study

Discovery of potent anti-toxoplasmosis drugs from secondary metabolites in Citrus limon (lemon) leaves, supported in-silico study

Abstract Toxoplasmosis induced by Toxoplasma gondii is a well-known health threat, that prompts fatal encephalitis increased with immunocompromised patients, in addition, it can cause chorioretinitis, microcephaly, stillbirth in the fetus and even led to death. Standard therapy uses sulfadiazine and...

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Bibliographic Details
Main Authors: Magdy Mostafa Desoky Mohammed, Hala Sh. Mohammed, Salwa A. Abu El Wafa, Doaa A. Ahmed, Elham A. Heikal, Islam Elgohary, Ashraf M. Barakat
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Citrus limon
Rutaceae
Toxoplasma Gondii
UPLC-ESI-MS/MS
Molecular docking
Molecular dynamics simulation
Online Access:https://doi.org/10.1038/s41598-024-82787-9
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https://doi.org/10.1038/s41598-024-82787-9

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