FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis

FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis

Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal parenchymal lung disease with limited therapeutic options, with fibroblast‐to‐myofibroblast transdifferentiation and hyperproliferation playing a major role. Investigating ex vivo‐cultured (myo)fibroblasts from human IPF lungs a...

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Main Authors: Hamza M Al‐Tamari, Swati Dabral, Anja Schmall, Pouya Sarvari, Clemens Ruppert, Jihye Paik, Ronald A DePinho, Friedrich Grimminger, Oliver Eickelberg, Andreas Guenther, Werner Seeger, Rajkumar Savai, Soni S Pullamsetti
Format: Article
Language:English
Published: Springer Nature 2017-12-01
Series:EMBO Molecular Medicine
Subjects:
fibroblast
forkhead box O transcription factors
idiopathic pulmonary fibrosis
myofibroblast
transdifferentiation
Online Access:https://doi.org/10.15252/emmm.201606261
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https://doi.org/10.15252/emmm.201606261

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