A novel drug prejudice scaffold-imidazopyridine-conjugate can promote cell death in a colorectal cancer model by binding to β-catenin and suppressing the Wnt signaling pathway

A novel drug prejudice scaffold-imidazopyridine-conjugate can promote cell death in a colorectal cancer model by binding to β-catenin and suppressing the Wnt signaling pathway

Introduction: Globally, colorectal cancer (CRC) is the third most common type of cancer, and its treatment frequently includes the utilization of drugs based on antibodies and small molecules. The development of CRC has been linked to various signaling pathways, with the Wnt/β-catenin pathway identi...

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Main Authors: Min Hee Yang, Basappa Basappa, Suresha N. Deveshegowda, Akshay Ravish, Arunkumar Mohan, Omantheswara Nagaraja, Mahendra Madegowda, Kanchugarakoppal S. Rangappa, Amudha Deivasigamani, Vijay Pandey, Peter E. Lobie, Kam Man Hui, Gautam Sethi, Kwang Seok Ahn
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Advanced Research
Subjects:
CHL-C
Wnt/ β −catenin
Apoptosis
Autophagy
Colorectal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224003059
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