The emergence of resistance to the antiparasitic selamectin in Mycobacterium smegmatis is improbable and contingent on cell wall integrity

The emergence of resistance to the antiparasitic selamectin in Mycobacterium smegmatis is improbable and contingent on cell wall integrity

ABSTRACT Tuberculosis remains the deadliest infectious disease of the 21st century. New antimicrobials are needed to improve treatment outcomes and enable therapy shortening. Drug repurposing is an alternative to the traditional drug discovery process. The avermectins are a family of macrocyclic lac...

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Main Authors: José Manuel Ezquerra-Aznárez, Henrich Gašparovič, Álvaro Chiner-Oms, Ainhoa Lucía, Jesús Blázquez, Iñaki Comas, Jana Korduláková, José A. Aínsa, Santiago Ramón-García
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:Microbiology Spectrum
Subjects:
Mycobacterium smegmatis
selamectin
repurposing
tuberculosis
mode of action
emergence of resistance
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02332-24
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https://journals.asm.org/doi/10.1128/spectrum.02332-24

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