The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate.

The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate.

A major challenge to developing a successful HIV vaccine is the vast diversity of viral sequences, yet it is generally assumed that an epitope conserved between different strains will be recognised by responding T-cells. We examined whether an invariant HLA-B8 restricted Nef₉₀₋₉₇ epitope FL8 shared...

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Main Authors: Srinika R F Ranasinghe, Holger B Kramer, Cynthia Wright, Benedikt M Kessler, Katalin di Gleria, Yonghong Zhang, Geraldine M Gillespie, Marie-Eve Blais, Abigail Culshaw, Tica Pichulik, Alison Simmons, Sarah L Rowland-Jones, Andrew J McMichael, Tao Dong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001341&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001341&type=printable

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