Patient-derived esophageal adenocarcinoma organ chip: a physiologically relevant platform for functional precision oncology

Abstract Background Esophageal adenocarcinoma (EAC) is the sixth most deadly cancer worldwide, with increasing incidence in North America. As no targeted therapy or immunotherapy has revolutionized the management of EAC, chemotherapy is the only standard of care. Most patients with EAC experience po...

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Bibliographic Details
Main Authors: Sanjima Pal, Elee Shimshoni, Salvador Flores Torres, Mingyang Kong, Kulsum Tai, Veena Sangwan, Nicholas Bertos, Swneke Donovan Bailey, Julie Bérubé, Donald E. Ingber, Lorenzo Ferri
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
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Online Access:https://doi.org/10.1186/s12967-025-06593-1
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