Thyrotropin levels in first-episode bipolar disorder and their association with clinical phenotypes: systematic review and meta-analysis

Thyrotropin levels in first-episode bipolar disorder and their association with clinical phenotypes: systematic review and meta-analysis

IntroductionThyroid hormones play a crucial role in brain function, yet the relationship between TSH and bipolar disorder remains unclear. This review aims to synthesize the current literature to clarify the interplay between serum TSH levels and both the phenotype and severity of bipolar disorder.M...

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Main Authors: Elisa Gatta, Virginia Maltese, Francesco Dondi, Pietro Bellini, Massimiliano Ugoccioni, Irene Silvestrini, Anna Ceraso, Antonio Vita, Mario Rotondi, Francesco Bertagna, Carlo Cappelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Endocrinology
Subjects:
thyroid
thyroid hormones
bipolar disorder
TSH
BD manic
BD depression
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1580854/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1580854/full

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