Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease.

Orientia tsutsugamushi is an obligate intracellular bacterium found in Leptotrombidium mites that causes the human disease scrub typhus. A distinguishing feature of O. tsutsugamushi is its extensive strain diversity, yet differences in virulence between strains are not well defined nor well understo...

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Main Authors: Panjaporn Chaichana, Naphat Satapoomin, Chitrasak Kullapanich, Suthida Chuenklin, Aisha Mohammad, Manutsanun Inthawong, Erin E Ball, Thomas P Burke, Piyanate Sunyakumthorn, Jeanne Salje
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012833
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