Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions

Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions

The Janus kinase/signal transducers and activators of transcription (JAK–STAT) control natural killer (NK) cells development and cytotoxic functions, however, whether long non-coding RNAs (lncRNAs) are involved in this pathway remains unknown. We found that miR155HG was elevated in activated NK cell...

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Main Authors: Songyang Li, Yongjie Liu, Xiaofeng Yin, Yao Yang, Xinjia Liu, Jiaxing Qiu, Qinglan Yang, Yana Li, Zhiguo Tan, Hongyan Peng, Peiwen Xiong, Shuting Wu, Lanlan Huang, Xiangyu Wang, Sulai Liu, Yuxing Gong, Yuan Gao, Lingling Zhang, Junping Wang, Yafei Deng, Zhaoyang Zhong, Youcai Deng
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
NK cells
iPSC-NK cells
lncRNA
miR155HG
Competing endogenous RNA
miR-6756
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352500111X
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