Pseudomonas aeruginosa enhances anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells

Pseudomonas aeruginosa enhances anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells

BackgroundImmune checkpoint therapy for colorectal cancer (CRC) has been found to be unsatisfactory for clinical treatment. Fecal microbiota transplantation (FMT) has been shown to remodel the intestinal flora, which may improve the therapeutic effect of αPD-1. Further exploration of key genera that...

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Bibliographic Details
Main Authors: Lu Chen, Guangcong Ruan, Xuefei Zhao, Ailin Yi, Zhifeng Xiao, Yuting Tian, Yi Cheng, Dongfeng Chen, Yanling Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
αPD-1
Pseudomonas aeruginosa
PA-MSHA
CRC
CD8+T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1553757/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1553757/full

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