Pathological complete response after monotherapy with immune checkpoint inhibitors for bifocal colon cancer in a patient with lynch syndrome and situs inversus totalis: a case report

Pathological complete response after monotherapy with immune checkpoint inhibitors for bifocal colon cancer in a patient with lynch syndrome and situs inversus totalis: a case report

BackgroundLynch syndrome is the most common hereditary colorectal cancer (CRC) syndrome, accounting for 3–5% of all CRC cases. Situs inversus totalis (SIT) is a rare congenital malformation with an incidence of 1 in 8,000 to 1 in 25,000. The co-occurrence of Lynch syndrome and SIT is extremely uncom...

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Main Authors: Jun Feng, Wenbo Niu, Juan Zhang, Yuanyi Ding, Zheng Li, Jianfeng Zhang, Baokun Li, Chenhui Li, Feifei Wang, Guiying Wang, Bin Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
situs inversus totalis
lynch syndrome
immune checkpoint inhibitors
pathological complete response
colon cancer
microsatellite instability-high
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571607/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571607/full

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