Clinical characteristics of EGFR-ctDNA shedders in EGFR-mutant NSCLC patients

Clinical characteristics of EGFR-ctDNA shedders in EGFR-mutant NSCLC patients

Background: Circulating tumor DNA (ctDNA) revolutionized the molecular diagnostics of lung cancer by enabling non-invasive, sensitive identification of actionable mutations. However, ctDNA analysis may be challenging due to tumor shedding variability, leading to false negative results. This study ai...

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Main Authors: Martina Ruglioni, Iacopo Petrini, Stefania Crucitta, Andrea Sbrana, Giovanna Irene Luculli, Leila Sadeghi Gol, Carola Forte, Antonio Chella, Christian Rolfo, Romano Danesi, Marzia Del Re
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Translational Oncology
Subjects:
Circulating-tumor DNA
NSCLC
Tumor shedding
Predictive biomarkers
mEGFR
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523324003541
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