Lack of adipocyte FAM20C improves whole body glucose homeostasis
Abstract FAM20C, a member of the family with sequence similarity 20, is involved in many physiological functions. Obesity, characterized by excessive accumulation of adipose tissue, has attracted more and more attention as a worldwide health problem. Here we generated adipocyte‐specific FAM20C knock...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70126 |
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| author | Liping Deng Yanshan Huang Feifei Zhao Puxin Chen Xiaohong Huang |
| author_facet | Liping Deng Yanshan Huang Feifei Zhao Puxin Chen Xiaohong Huang |
| author_sort | Liping Deng |
| collection | DOAJ |
| description | Abstract FAM20C, a member of the family with sequence similarity 20, is involved in many physiological functions. Obesity, characterized by excessive accumulation of adipose tissue, has attracted more and more attention as a worldwide health problem. Here we generated adipocyte‐specific FAM20C knockout mice to investigate the role of FAM20C in adipose tissue expansion and obesity. Our results demonstrate that knockout mice are protected against high fat diet‐induced obesity, adiposity, and fatty liver disease. Additionally, knockout mice exhibited improved metabolic phenotypes, including enhanced glucose tolerance and insulin sensitivity compared with control mice. Furthermore, we observed reduced inflammatory infiltration and collagen deposition in the adipose tissues of knockout mice. Taken together, our results indicate that targeting FAM20C in adipocytes may be a promising strategy for the treatment of obesity and associated metabolic disorders. |
| format | Article |
| id | doaj-art-a8ec03859d2f4afa960c9f108d8f1de1 |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-a8ec03859d2f4afa960c9f108d8f1de12025-01-25T06:41:00ZengWileyPhysiological Reports2051-817X2024-11-011221n/an/a10.14814/phy2.70126Lack of adipocyte FAM20C improves whole body glucose homeostasisLiping Deng0Yanshan Huang1Feifei Zhao2Puxin Chen3Xiaohong Huang4Department of Endocrinology Longgang District Central Hospital of Shenzhen Shenzhen Guangdong ChinaDivision of Preventive Health Longgang District Central Hospital of Shenzhen Shenzhen Guangdong ChinaDepartment of Nursing Shenzhen Clinical Medical College, Guangzhou University of Chinese Medicine Shenzhen Guangdong ChinaDepartment of Endocrinology Longgang District Central Hospital of Shenzhen Shenzhen Guangdong ChinaDepartment of Nursing Longgang District Central Hospital of Shenzhen Shenzhen Guangdong ChinaAbstract FAM20C, a member of the family with sequence similarity 20, is involved in many physiological functions. Obesity, characterized by excessive accumulation of adipose tissue, has attracted more and more attention as a worldwide health problem. Here we generated adipocyte‐specific FAM20C knockout mice to investigate the role of FAM20C in adipose tissue expansion and obesity. Our results demonstrate that knockout mice are protected against high fat diet‐induced obesity, adiposity, and fatty liver disease. Additionally, knockout mice exhibited improved metabolic phenotypes, including enhanced glucose tolerance and insulin sensitivity compared with control mice. Furthermore, we observed reduced inflammatory infiltration and collagen deposition in the adipose tissues of knockout mice. Taken together, our results indicate that targeting FAM20C in adipocytes may be a promising strategy for the treatment of obesity and associated metabolic disorders.https://doi.org/10.14814/phy2.70126adipose tissueFAM20cinflammationinsulin resistanceobesity |
| spellingShingle | Liping Deng Yanshan Huang Feifei Zhao Puxin Chen Xiaohong Huang Lack of adipocyte FAM20C improves whole body glucose homeostasis Physiological Reports adipose tissue FAM20c inflammation insulin resistance obesity |
| title | Lack of adipocyte FAM20C improves whole body glucose homeostasis |
| title_full | Lack of adipocyte FAM20C improves whole body glucose homeostasis |
| title_fullStr | Lack of adipocyte FAM20C improves whole body glucose homeostasis |
| title_full_unstemmed | Lack of adipocyte FAM20C improves whole body glucose homeostasis |
| title_short | Lack of adipocyte FAM20C improves whole body glucose homeostasis |
| title_sort | lack of adipocyte fam20c improves whole body glucose homeostasis |
| topic | adipose tissue FAM20c inflammation insulin resistance obesity |
| url | https://doi.org/10.14814/phy2.70126 |
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