Lack of adipocyte FAM20C improves whole body glucose homeostasis

Abstract FAM20C, a member of the family with sequence similarity 20, is involved in many physiological functions. Obesity, characterized by excessive accumulation of adipose tissue, has attracted more and more attention as a worldwide health problem. Here we generated adipocyte‐specific FAM20C knock...

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Main Authors: Liping Deng, Yanshan Huang, Feifei Zhao, Puxin Chen, Xiaohong Huang
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.70126
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author Liping Deng
Yanshan Huang
Feifei Zhao
Puxin Chen
Xiaohong Huang
author_facet Liping Deng
Yanshan Huang
Feifei Zhao
Puxin Chen
Xiaohong Huang
author_sort Liping Deng
collection DOAJ
description Abstract FAM20C, a member of the family with sequence similarity 20, is involved in many physiological functions. Obesity, characterized by excessive accumulation of adipose tissue, has attracted more and more attention as a worldwide health problem. Here we generated adipocyte‐specific FAM20C knockout mice to investigate the role of FAM20C in adipose tissue expansion and obesity. Our results demonstrate that knockout mice are protected against high fat diet‐induced obesity, adiposity, and fatty liver disease. Additionally, knockout mice exhibited improved metabolic phenotypes, including enhanced glucose tolerance and insulin sensitivity compared with control mice. Furthermore, we observed reduced inflammatory infiltration and collagen deposition in the adipose tissues of knockout mice. Taken together, our results indicate that targeting FAM20C in adipocytes may be a promising strategy for the treatment of obesity and associated metabolic disorders.
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institution Kabale University
issn 2051-817X
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publishDate 2024-11-01
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series Physiological Reports
spelling doaj-art-a8ec03859d2f4afa960c9f108d8f1de12025-01-25T06:41:00ZengWileyPhysiological Reports2051-817X2024-11-011221n/an/a10.14814/phy2.70126Lack of adipocyte FAM20C improves whole body glucose homeostasisLiping Deng0Yanshan Huang1Feifei Zhao2Puxin Chen3Xiaohong Huang4Department of Endocrinology Longgang District Central Hospital of Shenzhen Shenzhen Guangdong ChinaDivision of Preventive Health Longgang District Central Hospital of Shenzhen Shenzhen Guangdong ChinaDepartment of Nursing Shenzhen Clinical Medical College, Guangzhou University of Chinese Medicine Shenzhen Guangdong ChinaDepartment of Endocrinology Longgang District Central Hospital of Shenzhen Shenzhen Guangdong ChinaDepartment of Nursing Longgang District Central Hospital of Shenzhen Shenzhen Guangdong ChinaAbstract FAM20C, a member of the family with sequence similarity 20, is involved in many physiological functions. Obesity, characterized by excessive accumulation of adipose tissue, has attracted more and more attention as a worldwide health problem. Here we generated adipocyte‐specific FAM20C knockout mice to investigate the role of FAM20C in adipose tissue expansion and obesity. Our results demonstrate that knockout mice are protected against high fat diet‐induced obesity, adiposity, and fatty liver disease. Additionally, knockout mice exhibited improved metabolic phenotypes, including enhanced glucose tolerance and insulin sensitivity compared with control mice. Furthermore, we observed reduced inflammatory infiltration and collagen deposition in the adipose tissues of knockout mice. Taken together, our results indicate that targeting FAM20C in adipocytes may be a promising strategy for the treatment of obesity and associated metabolic disorders.https://doi.org/10.14814/phy2.70126adipose tissueFAM20cinflammationinsulin resistanceobesity
spellingShingle Liping Deng
Yanshan Huang
Feifei Zhao
Puxin Chen
Xiaohong Huang
Lack of adipocyte FAM20C improves whole body glucose homeostasis
Physiological Reports
adipose tissue
FAM20c
inflammation
insulin resistance
obesity
title Lack of adipocyte FAM20C improves whole body glucose homeostasis
title_full Lack of adipocyte FAM20C improves whole body glucose homeostasis
title_fullStr Lack of adipocyte FAM20C improves whole body glucose homeostasis
title_full_unstemmed Lack of adipocyte FAM20C improves whole body glucose homeostasis
title_short Lack of adipocyte FAM20C improves whole body glucose homeostasis
title_sort lack of adipocyte fam20c improves whole body glucose homeostasis
topic adipose tissue
FAM20c
inflammation
insulin resistance
obesity
url https://doi.org/10.14814/phy2.70126
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AT yanshanhuang lackofadipocytefam20cimproveswholebodyglucosehomeostasis
AT feifeizhao lackofadipocytefam20cimproveswholebodyglucosehomeostasis
AT puxinchen lackofadipocytefam20cimproveswholebodyglucosehomeostasis
AT xiaohonghuang lackofadipocytefam20cimproveswholebodyglucosehomeostasis