Baicalin targets YTHDC2 and alleviates male reproductive toxicity caused by co-exposure to nanoplastics and manganese through m6A-dependent pathway

Baicalin targets YTHDC2 and alleviates male reproductive toxicity caused by co-exposure to nanoplastics and manganese through m6A-dependent pathway

Abstract Nanoplastics (NPs) pollution has become a pressing global environmental issue. NPs possess the ability to adsorb heavy metals, thereby acting as vectors that facilitate the entry of these toxic substances into living organisms. However, the synergistic toxic effects of NPs and heavy metals,...

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Bibliographic Details
Main Authors: Yi Wen, Tingwei Pan, Lu Liu, Jinning Wang, Kexin Yang, Zhushan Fu, Wenhao Li, XinMiao Wang, Zhiru Shen, Yan Li, Yinke Du, Yu Deng
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Nanobiotechnology
Subjects:
Polystyrene nanoplastics
Manganese
Male reproductive toxicity
m6A
Mdm2-p53 Pathway
Baicalin
Online Access:https://doi.org/10.1186/s12951-025-03535-3
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https://doi.org/10.1186/s12951-025-03535-3

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