Subtle alteration in transcriptional memory governs the lineage-level cell cycle duration heterogeneities of mammalian cells
Summary: Cell cycle duration heterogeneities within a malignant tumor significantly reduce the therapeutic efficacy of cancer treatment. However, identifying factors governing such heterogeneities remains challenging. Herein, we perform a computational modeling study to demonstrate that correlated f...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225012428 |
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