Efficacy and safety of third-generation CD19-CAR T cells incorporating CD28 and TLR2 intracellular domains for B-cell malignancies with central nervous system involvement: results of a pivotal trial

Efficacy and safety of third-generation CD19-CAR T cells incorporating CD28 and TLR2 intracellular domains for B-cell malignancies with central nervous system involvement: results of a pivotal trial

Abstract Background Third‑generation CAR-T cells demonstrated promising efficacy and remarkably low toxicity in refractory or relapsed (R/R) B-cell malignancies. However, data on the patients with central nervous system (CNS) involvement are limited due to concerns regarding treatment-related neurot...

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Main Authors: Bailin He, Ren Lin, Na Xu, Le Qin, Zhixiang Wang, Qiang Wang, Xiaofang Li, Xiaolei Wei, Yongqiang Wei, Zhaoyang Tang, Zhiping Fan, Fen Huang, Xiaoli Liu, Jing Sun, Li Xuan, Peng Li, Hongsheng Zhou, Qifa Liu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
CAR T cell therapy
B-cell malignancies
Central nervous system involvement
Third-generation CAR
TLR2 co-stimulation
Online Access:https://doi.org/10.1186/s12967-025-06608-x
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https://doi.org/10.1186/s12967-025-06608-x

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