Translocator protein deficiency blocks the ferroptosis of malignant peripheral nerve sheath tumors through glutathione peroxidase 4

Translocator protein deficiency blocks the ferroptosis of malignant peripheral nerve sheath tumors through glutathione peroxidase 4

BackgroundMalignant peripheral nerve sheath tumor (MPNST) is an aggressive soft tissue sarcoma characterized by high recurrence and poor prognosis, necessitating the search for novel therapeutic targets and strategies. This study investigated the expression of mitochondrial translocator protein (TSP...

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Bibliographic Details
Main Authors: Xiaoli Zhang, Zhuonan Pu, Chun Ran, Xingnan Zhang, Chao Guo, Yuxuan Deng, Jinqiu Liu, Yingdan Chen, Jie Feng, Song Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
malignant peripheral nerve sheath tumor
translocator protein
ferroptosis
lipid peroxidation
glutathione peroxidase 4
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1624817/full
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https://www.frontiersin.org/articles/10.3389/fncel.2025.1624817/full

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