ADAM Sheddase Activity Promotes the Detachment of Small Extracellular Vesicles From the Plasma Membrane

ADAM Sheddase Activity Promotes the Detachment of Small Extracellular Vesicles From the Plasma Membrane

ABSTRACT Small extracellular vesicles (SEVs) are involved in diverse functions in normal and pathological situations, including intercellular communication, immunity, metastasis and neurodegeneration. Cell release of SEVs is assumed to occur passively right after multivesicular bodies of the endocyt...

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Main Authors: Chloé Bizingre, Zaira Arellano‐Anaya, Flavien Picard, Mathéa Pietri, Anne Baudry, Florence Roussel, Clara Bianchi, Aurélie Alleaume‐Butaux, Hector Ardila‐Osorio, Maryse Romao, Grégory Lavieu, Graça Raposo, Benoit Schneider
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Journal of Extracellular Vesicles
Subjects:
ERK1/2
exosomes
iRhom2
PDK1
protein cleavage
RSK2
Online Access:https://doi.org/10.1002/jev2.70114
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https://doi.org/10.1002/jev2.70114

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