Encapsulation of Carvedilol in Nanomicelles Improves Central Hemodynamics and Target Organ Damage Protection in Spontaneously Hypertensive Rats

Encapsulation of Carvedilol in Nanomicelles Improves Central Hemodynamics and Target Organ Damage Protection in Spontaneously Hypertensive Rats

ABSTRACT The hypothesis of this work was that chronic treatment with carvedilol (CAR) administered in a nanomicelles‐based formulation (CAR‐NMs), which increases CAR oral bioavailability, is more effective than a conventional liquid CAR formulation (CAR‐LCF) and is comparable to chronic treatment wi...

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Main Authors: Luciano Parola, Paula Denise Prince, Javier Alberto Walter Opezzo, Jennifer Riedel, Miguel Ángel Allo, Yanina Alejandra Santander Plantamura, Eliana P. Bin, Germán E. González, Andrea Carranza, Martín Donato, Diego A. Chiappetta, Marcela A. Moretton, Christian Höcht
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Pharmacology Research & Perspectives
Subjects:
blood pressure variability
carvedilol
central blood pressure
hypertension
losartan
nanomicelles
Online Access:https://doi.org/10.1002/prp2.70125
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https://doi.org/10.1002/prp2.70125

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