Reduced DNMT1 expression associated with TP53 promoter hypomethylation mediate enhanced granulosa cell senescence during ovarian aging

Reduced DNMT1 expression associated with TP53 promoter hypomethylation mediate enhanced granulosa cell senescence during ovarian aging

Background The effects of granulose cell (GC) senescence on premature ovarian insufficiency/premature ovarian failure have been extensively examined, the association between GC senescence and ovarian aging remains to be clarified.Methods Human and mouse GCs from young/control and old/advanced matern...

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Bibliographic Details
Main Authors: Hui Guo, Shu-Hong Pan, Jian Zhao, De-Xian Kong, Cai-Ping Geng, Sui-Bing Miao
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gynecological Endocrinology
Subjects:
Senescence
granulosa cell
ovarian aging
methylation
DNA-methyltransferase 1
Online Access:https://www.tandfonline.com/doi/10.1080/09513590.2025.2471549
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https://www.tandfonline.com/doi/10.1080/09513590.2025.2471549

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