Defining subgroups of pediatric nephrotic patients with urine proteomics

Defining subgroups of pediatric nephrotic patients with urine proteomics

Abstract The molecular pathophysiology of nephrotic syndrome remains largely elusive in pediatric patients. While most children with minimal change disease (MCD) show favorable responses to immunosuppressive therapy, those with focal segmental glomerulosclerosis (FSGS) often exhibit poorer treatment...

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Main Authors: Timothy D. Cummins, Laura H. Mariani, Daniel W. Wilkey, Saeed A. Jortani, Margaret Helmuth, Madhavi J. Rane, Michael L. Merchant, Yu Kamigaki, Chandra Theesfeld, Phillip J. McCown, Wenjun Ju, Julie A. Dougherty, Susan McRitchie, Wimal Pathmasiri, Matthias Kretzler, Susan J. Sumner, William E. Smoyer, Jon B. Klein, Cure Glomerulonephropathy (CureGN) Consortium
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Urine biomarker
Proteomics
Nephrotic proteinuria
FSGS
MCD
Pediatric glomerular disease
Online Access:https://doi.org/10.1038/s41598-025-05150-6
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https://doi.org/10.1038/s41598-025-05150-6

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