2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity

2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity

IntroductionThe development of new drugs for Alzheimer’s disease (AD) remains a major challenge due to the disorder’s complex and multifactorial nature. 2′-Fucosyllactose (2′-FL), a human milk oligosaccharide, has demonstrated promising neuroprotective properties. However, its effects on AD-related...

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Bibliographic Details
Main Authors: Yeasmin Akter Munni, Khoa Nguyen Tran, Seon-Min Jeon, Meeyul Hwang, Jong-Won Yoon, Young-Ha Song, Tae Woo Oh, Sang Il Gum, In-Jun Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
2′-fucosyllactose
Alzheimer’s disease
cognitive function
oxidative stress
synaptic plasticity
5xFAD
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1598030/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1598030/full

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