Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H2O2

Differences in cancer and normal cell oxidative metabolism provide a unique therapeutic opportunity for developing combined modality approaches with redox-active small molecules as radio-chemosensitizers that are well-tolerated by normal tissues. Pentaazamacrocyclic Mn (II)-containing (MnPAM) supero...

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Main Authors:	C.F. Pulliam, M.A. Fath, S. Sho, S.T. Johnson, B.A. Wagner, M. Singhania, A.L. Kalen, K. Bayanbold, S.R. Solst, B.G. Allen, B.N. George, J.M. Caster, G.R. Buettner, D.P. Riley, J.L. Keene, R.A. Beardsley, D.R. Spitz
Format:	Article
Language:	English
Published:	Elsevier 2025-03-01
Series:	Redox Biology
Subjects:	SOD mimetics (dismutase mimetics) Rucospasem (RUC) Non-small cell lung cancer (NSCLC) Pharmacological ascorbate (P-AscH‾ IV ascorbate [mM] plasma levels) Hydrogen peroxide (H2O2)
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231725000187
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http://www.sciencedirect.com/science/article/pii/S2213231725000187

Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H2O2

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