The commonly used antibiotic streptomycin reduces protein synthesis and differentiation in cultured C2C12 myotubes

The commonly used antibiotic streptomycin reduces protein synthesis and differentiation in cultured C2C12 myotubes

Abstract The antibiotic streptomycin is an integral part of cell culture medium. Because streptomycin inhibits bacterial protein synthesis, streptomycin might also have off‐target effects on muscle cell function. Here, we studied the effect of streptomycin on C2C12 myoblasts, myofiber growth, and me...

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Bibliographic Details
Main Authors: Chuqi He, Moritz Eggelbusch, Jelle Y. Huijts, Andi Shi, Gerard J. deWit, Carla Offringa, Richard T. Jaspers, Rob C. I. Wüst
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Physiological Reports
Subjects:
antibiotics
atrophy
metabolism
protein synthesis
skeletal muscle
streptomycin
Online Access:https://doi.org/10.14814/phy2.70353
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https://doi.org/10.14814/phy2.70353

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