Broadening the ARMC2 mutational phenotype: linking multiple morphological abnormalities of the Flagella to Pulmonary Manifestations in Primary Ciliary Dyskinesia

Broadening the ARMC2 mutational phenotype: linking multiple morphological abnormalities of the Flagella to Pulmonary Manifestations in Primary Ciliary Dyskinesia

Abstract Background Severe asthenoteratozoospermia, a prevalent cause of male infertility, has increasingly been associated with ARMC2 variants that cause Multiple Morphological Abnormalities of the Sperm Flagella (MMAF). Although ARMC2 is also expressed in other ciliary structures, no studies have...

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Main Authors: Baoyan Wu, Wenhao Zhang, Hui Yu, Lewen Ruan, Kai Wang, Meng Gu, Hao Geng, Jiajun Fang, Chuan Xu, Yuying Sheng, Qing Tan, Qunshan Shen, Zongliu Duan, Huan Wu, Rong Hua, Rui Guo, Zhaolian Wei, Ping Zhou, Yuping Xu, Yunxia Cao, Xiaojin He, Kuokuo Li, Mingrong Lv, Dongdong Tang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Reproductive Biology and Endocrinology
Subjects:
Male infertility
MMAF
PCD
Flagellum
Cilla
ARMC2
Online Access:https://doi.org/10.1186/s12958-025-01385-0
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https://doi.org/10.1186/s12958-025-01385-0

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