3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects
Clinically, infectious bone defects represent a significant threat, leading to osteonecrosis, severely compromising patient prognosis, and prolonging hospital stays. Thus, there is an urgent need to develop a bone graft substitute that combines broad-spectrum antibacterial efficacy and bone-inductiv...
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24004997 |
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| author | Kai Chen Fang Wang Xiumei Sun Wenwei Ge Mingjun Zhang Lin Wang Haoyu Zheng Shikang Zheng Haoyu Tang Zhengjie Zhou Guomin Wu |
| author_facet | Kai Chen Fang Wang Xiumei Sun Wenwei Ge Mingjun Zhang Lin Wang Haoyu Zheng Shikang Zheng Haoyu Tang Zhengjie Zhou Guomin Wu |
| author_sort | Kai Chen |
| collection | DOAJ |
| description | Clinically, infectious bone defects represent a significant threat, leading to osteonecrosis, severely compromising patient prognosis, and prolonging hospital stays. Thus, there is an urgent need to develop a bone graft substitute that combines broad-spectrum antibacterial efficacy and bone-inductive properties, providing an effective treatment option for infectious bone defects. In this study, the precision of digital light processing (DLP) 3D printing technology was utilized to construct a scaffold, incorporating zinc oxide nanoparticles (ZnO-NPs) modified barium titanate (BT) with hydroxyapatite (HA), resulting in a piezoelectric ceramic scaffold designed for the repair of infected bone defects. The results indicated that the addition of ZnO-NPs significantly improved the piezoelectric properties of BT, facilitating a higher HA content within the ceramic scaffold system, which is essential for bone regeneration. In vitro antibacterial assessments highlighted the scaffold's potent antibacterial capabilities. Moreover, combining the synergistic effects of low-intensity pulsed ultrasound (LIPUS) and piezoelectricity, results demonstrated that the scaffold promoted notable osteogenic and angiogenic potential, enhancing bone growth and repair. Furthermore, transcriptomics analysis results suggested that the early growth response-1 (EGR1) gene might be crucial in this process. This study introduces a novel method for constructing piezoelectric ceramic scaffolds exhibiting outstanding osteogenic, angiogenic, and antibacterial properties under the combined influence of LIPUS, offering a promising treatment strategy for infectious bone defects. |
| format | Article |
| id | doaj-art-a8092b3a82c5451798d881a840220c93 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-a8092b3a82c5451798d881a840220c932025-01-26T05:04:22ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-03-01454794953D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defectsKai Chen0Fang Wang1Xiumei Sun2Wenwei Ge3Mingjun Zhang4Lin Wang5Haoyu Zheng6Shikang Zheng7Haoyu Tang8Zhengjie Zhou9Guomin Wu10Department of Oral, Plastic and Aesthetic Surgery, Hospital of Stomatology, Jilin University, Changchun, 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, ChinaDepartment of Orthodontics, Hospital of Stomatology, Jilin University, Changchun, 130021, ChinaKey Laboratory of Automobile Materials of Ministry of Education, School of Materials Science and Engineering, Jilin University, Changchun, 130021, ChinaDepartment of Oral, Plastic and Aesthetic Surgery, Hospital of Stomatology, Jilin University, Changchun, 130021, ChinaDepartment of Oral, Plastic and Aesthetic Surgery, Hospital of Stomatology, Jilin University, Changchun, 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, ChinaDepartment of Oral, Plastic and Aesthetic Surgery, Hospital of Stomatology, Jilin University, Changchun, 130021, ChinaKey Laboratory of Automobile Materials of Ministry of Education, School of Materials Science and Engineering, Jilin University, Changchun, 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, ChinaDepartment of Oral, Plastic and Aesthetic Surgery, Hospital of Stomatology, Jilin University, Changchun, 130021, China; Corresponding author.Clinically, infectious bone defects represent a significant threat, leading to osteonecrosis, severely compromising patient prognosis, and prolonging hospital stays. Thus, there is an urgent need to develop a bone graft substitute that combines broad-spectrum antibacterial efficacy and bone-inductive properties, providing an effective treatment option for infectious bone defects. In this study, the precision of digital light processing (DLP) 3D printing technology was utilized to construct a scaffold, incorporating zinc oxide nanoparticles (ZnO-NPs) modified barium titanate (BT) with hydroxyapatite (HA), resulting in a piezoelectric ceramic scaffold designed for the repair of infected bone defects. The results indicated that the addition of ZnO-NPs significantly improved the piezoelectric properties of BT, facilitating a higher HA content within the ceramic scaffold system, which is essential for bone regeneration. In vitro antibacterial assessments highlighted the scaffold's potent antibacterial capabilities. Moreover, combining the synergistic effects of low-intensity pulsed ultrasound (LIPUS) and piezoelectricity, results demonstrated that the scaffold promoted notable osteogenic and angiogenic potential, enhancing bone growth and repair. Furthermore, transcriptomics analysis results suggested that the early growth response-1 (EGR1) gene might be crucial in this process. This study introduces a novel method for constructing piezoelectric ceramic scaffolds exhibiting outstanding osteogenic, angiogenic, and antibacterial properties under the combined influence of LIPUS, offering a promising treatment strategy for infectious bone defects.http://www.sciencedirect.com/science/article/pii/S2452199X24004997Piezoelectric ceramicsZinc oxide nanoparticlesAntibacterial therapyBone regenerationLow-intensity pulsed ultrasound |
| spellingShingle | Kai Chen Fang Wang Xiumei Sun Wenwei Ge Mingjun Zhang Lin Wang Haoyu Zheng Shikang Zheng Haoyu Tang Zhengjie Zhou Guomin Wu 3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects Bioactive Materials Piezoelectric ceramics Zinc oxide nanoparticles Antibacterial therapy Bone regeneration Low-intensity pulsed ultrasound |
| title | 3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects |
| title_full | 3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects |
| title_fullStr | 3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects |
| title_full_unstemmed | 3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects |
| title_short | 3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects |
| title_sort | 3d printed zinc oxide nanoparticles modified barium titanate hydroxyapatite ultrasound responsive piezoelectric ceramic composite scaffold for treating infected bone defects |
| topic | Piezoelectric ceramics Zinc oxide nanoparticles Antibacterial therapy Bone regeneration Low-intensity pulsed ultrasound |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24004997 |
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