Coinheritance of polymorphic alleles of PIEZO1, G6PD and HBB enhances protection against malaria

Coinheritance of polymorphic alleles of PIEZO1, G6PD and HBB enhances protection against malaria

Malaria has exerted potent selective pressure on the human genome over millennia and has been a significant force in shaping human evolution. We have determined in 424 individuals living in malaria-hyperendemic areas in Ghana and in the Democratic Republic of Congo, the genotypes at the loci PIEZO1,...

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Main Authors: Paloma Abad, Susana Pérez-Benavente, Sara Pérez-Luz, Julius N. Fobil, Batisseur Kitenge Luyenga, André Kazadi Mukendi, Antonio Puyet, Amalia Diez, Lucio Luzzatto, Isabel G. Azcárate, José M. Bautista
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:One Health
Subjects:
Malaria
Piezo1
G6PD
Hemoglobin
PKLR
Sickle cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2352771425000874
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