APOE Drives Glioma Progression by Modulating CCL5/CCR5 Signaling in the Tumor Microenvironment and Inducing M2 Macrophage Polarization

APOE Drives Glioma Progression by Modulating CCL5/CCR5 Signaling in the Tumor Microenvironment and Inducing M2 Macrophage Polarization

Background: Tumor-associated macrophages (TAMs) are pivotal in shaping the tumor microenvironment (TME) during cancer progression. Emerging evidence indicates that dysregulation of key signaling pathways in cancer cells drives the secretion of various cytokines, modulating TAMs function. This study...

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Bibliographic Details
Main Authors: Wei Huang, Weimin Li, Xingyu Chen, Chengwei Xiang, Ke Luo
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Immunobiology
Subjects:
Glioblastoma
Tumor microenvironment
APOE
Tumor-associated Macrophages
CCL5-CCR5 signaling pathway
Immunosuppressive Mechanisms
Online Access:http://www.sciencedirect.com/science/article/pii/S0171298525000294
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http://www.sciencedirect.com/science/article/pii/S0171298525000294

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