Synaptic enrichment of pSer129 alpha-synuclein correlates with dopaminergic denervation in early-stage Parkinson’s disease

Synaptic enrichment of pSer129 alpha-synuclein correlates with dopaminergic denervation in early-stage Parkinson’s disease

Abstract In Parkinson’s disease (PD), α-synuclein aggregation in striatal synapses is hypothesised to trigger a cascade of events leading to synaptic loss and cortical Lewy body (LB) pathology. Using multiplex immunofluorescence and confocal microscopy on 69 brains spanning Braak stages 0–6—includin...

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Main Authors: Irene Frigerio, Martino L. Morella, Amber B. Winkelaar, Danai T. Vorgia, John JP Brevé, Walter A. Boiten, Bram L. van der Gaag, Ismael L. Calandri, Allert J. Jonker, Henk W. Berendse, Daniel Mona, Markus Britschgi, Laura E. Jonkman, Wilma DJ van de Berg
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61052-1
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https://doi.org/10.1038/s41467-025-61052-1

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