Technical considerations for using intravenous gadolinium-based-contrast-agent (GBCA) based MRI approaches to study cerebrospinal fluid (CSF) circulation and clearance

Technical considerations for using intravenous gadolinium-based-contrast-agent (GBCA) based MRI approaches to study cerebrospinal fluid (CSF) circulation and clearance

Intravenously (IV) administered Gadolinium-based-contrast-agents (GBCAs) can enter the intracranial cerebrospinal-fluid (CSF) space via weak barriers between blood and CSF at multiple locations in the brain. This enables IV-GBCAs to be used as a tracer to study CSF circulation and clearance in the b...

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Bibliographic Details
Main Authors: Jun Hua, Yuanqi Sun, Yinghao Li, Xinyi Zhou, Yuhan Bian, Adrian Paez, Briana Meyer, Swati Rane Levendovszky
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:NeuroImage
Subjects:
Partial volume
Concentration
Extracranial
Intracranial
Cerebrovasculature
Reference signal
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811925002423
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