Gut‐derived Lactobacillus from exceptional responders mitigates chemoradiotherapy‐induced intestinal injury through methionine‐driven epigenetic modulation

Gut‐derived Lactobacillus from exceptional responders mitigates chemoradiotherapy‐induced intestinal injury through methionine‐driven epigenetic modulation

Abstract Acute chemoradiotherapy‐induced intestinal injury (ACRIII) is a common and debilitating complication in patients with colorectal cancer, significantly impairing both quality of life and treatment outcomes. This study aimed to investigate the role of the gut microbiome in mitigating ACRIII....

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Main Authors: Lu Yu, Zhenhui Chen, Shengqi Yin, Qiqing Guo, Yuchuan Chen, Jiaying Li, Yafang Wang, Xiangqiang Liu, Zi Xu, Yaowei Zhang, Yuqin Zhang, Zhihao Zheng, Keli Chen, Yanqing Ding, Hongying Fan, Zhifeng Liu, Yi Ding
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:iMeta
Subjects:
acute chemoradiotherapy‐induced intestinal injury
Lactobacillus
Lacticaseibacillus rhamnosus DY801
Lti cells
methionine metabolism
metB
Online Access:https://doi.org/10.1002/imt2.70043
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https://doi.org/10.1002/imt2.70043

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