Toxoplasma gondii-induced activation of EGFR prevents autophagy protein-mediated killing of the parasite.

Toxoplasma gondii resides in an intracellular compartment (parasitophorous vacuole) that excludes transmembrane molecules required for endosome-lysosome recruitment. Thus, the parasite survives by avoiding lysosomal degradation. However, autophagy can re-route the parasitophorous vacuole to the lyso...

Full description

Saved in:
Bibliographic Details
Main Authors: Luis Muniz-Feliciano, Jennifer Van Grol, Jose-Andres C Portillo, Lloyd Liew, Bing Liu, Cathleen R Carlin, Vern B Carruthers, Stephen Matthews, Carlos S Subauste
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1003809
Tags: Add Tag
No Tags, Be the first to tag this record!