De Novo donor-specific anti-HLA antibody risk stratification in kidney transplantation using a combination of B cell and T cell molecular mismatch assessment

De Novo donor-specific anti-HLA antibody risk stratification in kidney transplantation using a combination of B cell and T cell molecular mismatch assessment

IntroductionThe presence of de novo donor-specific antibody (dnDSA) has detrimental effect on allograft outcomes in kidney transplantation. As humoral responses in transplantation are elicited targeting non-self-epitopes on donor HLA proteins, assessing HLA mismatches at the molecular level provides...

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Bibliographic Details
Main Authors: Elaine Chou-Wu, Matthias Niemann, Danny Youngs, Idoia Gimferrer
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
HLA molecular mismatch
major histocompatibility complex (MHC)
risk stratification
kidney transplantation
de novo DSA
Snow
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1508796/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1508796/full

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