Molecular mechanism of Activin receptor inhibition by DLK1

Abstract Delta-like non-canonical Notch ligand 1 (DLK1) influences myogenesis, adipogenesis, and other aspects of human development through a process that is largely attributed to the downregulation of Notch signaling. Here, we show that DLK1 does not bind to Notch receptors or affect ligand-mediate...

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Bibliographic Details
Main Authors: Daniel Antfolk, Qianqian Ming, Anna Manturova, Erich J. Goebel, Thomas B. Thompson, Vincent C. Luca
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60634-3
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