Spatial profiling reveals unique immune microenvironment in premenopausal triple-negative breast cancer associated with therapy response

Spatial profiling reveals unique immune microenvironment in premenopausal triple-negative breast cancer associated with therapy response

Abstract Background Triple-negative breast cancer (TNBC) lacks targeted therapies, leading to a poor prognosis. Younger patients with TNBC often present with aggressive disease and exhibit distinct tumor microenvironments (TME). We performed spatial profiling to understand the influence of menopausa...

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Main Authors: Vidya P. Nimbalkar, V. P. Snijesh, Savitha Rajarajan, C. E. Anupama, S. Mahalakshmi, Annie Alexander, Deshica Dechamma, Manju Moorthy, Gopalakrishna Ramaswamy, Rakesh Ramesh, B. S. Srinath, Jyothi S. Prabhu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Triple negative breast cancer
Premenopausal
Digital spatial profiling
Tumor microenvironment
Immune profiling
Therapy response
Online Access:https://doi.org/10.1186/s12967-025-06786-8
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https://doi.org/10.1186/s12967-025-06786-8

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