High vs. low vancomycin therapeutic concentrations in periprosthetic joint infection: A retrospective cohort analysis

High vs. low vancomycin therapeutic concentrations in periprosthetic joint infection: A retrospective cohort analysis

ObjectiveCurrent guidelines recommend vancomycin concentrations of 10–20 μg/mL for most infections, with higher levels (15–20 μg/mL) suggested for severe cases. However, evidence supporting these recommendations in periprosthetic joint infection (PJI) is limited. This study aims to evaluate the impa...

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Bibliographic Details
Main Authors: Jingdong Cheng, Dehua Wang, Yanqing Chen, Qingqing Zhao, Qianyi Ou, Liangming Zhang, Xinyu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
vancomycin
therapeutic drug monitoring
periprosthetic joint infection
treatment effectiveness
treatment safety
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1555276/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1555276/full

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