Study on the mechanism of Shuanghe decoction against steroid-induced osteonecrosis of the femoral head: insights from network pharmacology, metabolomics, and gut microbiota

Study on the mechanism of Shuanghe decoction against steroid-induced osteonecrosis of the femoral head: insights from network pharmacology, metabolomics, and gut microbiota

Abstract Background Steroid-induced osteonecrosis of the femoral head (SONFH) is a challenging and debilitating orthopedic condition with a rising incidence in recent years. Shuanghe Decoction (SHD), a traditional Chinese medicine formula, has shown significant efficacy in treating SONFH, though its...

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Bibliographic Details
Main Authors: Kai Zhu, Wanxin Liu, Yuanyuan Peng, Xiaoqiang Wang, Zhenhao Wang, Jun Zheng, Guoying Deng, Qiugen Wang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Shuanghe decoction
Steroid-induced osteonecrosis of the femoral head
Network pharmacology
Metabolomics
Gut microbiota
Online Access:https://doi.org/10.1186/s13018-025-05619-0
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https://doi.org/10.1186/s13018-025-05619-0

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