Resveratrol and Its Metabolite as Potential Allosteric Regulators of Monoamine Oxidase A Activity in the Brain and Liver Under Chronic Predator Stress

Resveratrol and Its Metabolite as Potential Allosteric Regulators of Monoamine Oxidase A Activity in the Brain and Liver Under Chronic Predator Stress

<b>Background</b>: Resveratrol has been shown to modulate stress-related anxiety by reducing brain monoamine oxidase A (MAO-A) activity. However, the molecular mechanism underlying this neurochemical effect remains unknown. In this study, we employed in silico approaches to investigate t...

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Bibliographic Details
Main Authors: Jurica Novak, Olga B. Tseilikman, Vladislav A. Shatilov, Maxim S. Zhukov, Vadim A. Shevyrin, Zuhra R. Khismatullina, Albina M. Fedorova, Georgiy N. Patrikyan, Timur L. Khaibullin, Vadim E. Tseilikman
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomedicines
Subjects:
resveratrol
monoamine oxidase
serotonin
<i>trans</i>-resveratrol-3-<i>O</i>-glucuronide
allostery
Online Access:https://www.mdpi.com/2227-9059/13/5/1196
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