Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice

Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice

BackgroundAlzheimer’s disease (AD) is a common neurodegenerative disorder affecting older adults, characterized by progressive cognitive decline and pathological features such as amyloid plaque deposition, neuronal loss, and synaptic reduction. RNA N6-methyladenosine (m6A) methylation is prevalent i...

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Main Authors: Huan Chen, Fangzhen Guo, Yan Zhao, Wei Liu, Bingyu Chen, Chang Wang, Lining Huang, Sufang Jiang, Xiaowei Ma, Huiling Ren, Sha Li, Huixian Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
m6A methylation modification
METTL16
MAT2A
learning and memory
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1572976/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1572976/full

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