Lactic acid bacteria as microbial cell factories for the in vivo delivery of therapeutic proteins as secretable TAT fusion products

Lactic acid bacteria as microbial cell factories for the in vivo delivery of therapeutic proteins as secretable TAT fusion products

Abstract Protein-based therapeutics have garnered increasing attention across various medical fields for their substantial benefits to human health. Existing strategies for intracellular protein delivery, such as cell-penetrating peptide (CPP)-based approaches, including the transactivator of transc...

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Main Authors: Giorgio Medici, Giulia Candini, Nicola Mottolese, Beatrice Uguagliati, Federica Trebbi, Manuela Loi, Angelica Marina Bove, Spase Stojanov, Erika Esposito, Rosalba Vitagliano, Federica D’Amico, Silvia Turroni, Jessica Fiori, Aleš Berlec, Stefania Trazzi, Elisabetta Ciani
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Biological Engineering
Subjects:
Lactococcus lactis
Live delivery system
Protein replacement therapy
Cell-penetrating peptides
Online Access:https://doi.org/10.1186/s13036-025-00538-4
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https://doi.org/10.1186/s13036-025-00538-4

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