Uncovering key markers and therapeutic targets for renal fibrosis in diabetic kidney disease through bulk and single-cell RNA sequencing

Uncovering key markers and therapeutic targets for renal fibrosis in diabetic kidney disease through bulk and single-cell RNA sequencing

Abstract Background Diabetic kidney disease (DKD) is the major cause of chronic kidney failure, with tubulointerstitial fibrosis playing a crucial role in disease development. Identifying fibrosis-related genes is crucial for improving diagnosis and developing novel therapies due to the necessity fo...

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Main Authors: Lijuan Li, Mi Tao, Xueyun Gao, Quan Cao, Zejing Liao, Feng Chen, Ayinigaer Yusufu, Haihang Nie, Ziyue Zeng, Kai Huang, Xuan Deng, Ping Gao, Xiaoyan Wu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Diabetic kidney disease
Renal fibrosis
PROM1
THY1
Biomarkers
Single-cell RNA sequencing
Online Access:https://doi.org/10.1186/s12967-025-06554-8
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https://doi.org/10.1186/s12967-025-06554-8

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