Gut microbe-derived aromatic trace amines mediate individual variability in response to herbal medicine CDD-2101 for functional constipation

Gut microbe-derived aromatic trace amines mediate individual variability in response to herbal medicine CDD-2101 for functional constipation

Functional constipation (FC), a common gastrointestinal disorder, poses significant therapeutic challenges due to the limited efficacy and durability of current therapies. A novel strategy for addressing FC involves the targeting of gut dysbiosis. Our previous study demonstrated that the botanical d...

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Main Authors: Shifa Ruan, Yaqi Li, Ziwan Ning, Yunlyu Li, Qin Liu, Wenyu Fang, Xuanting Jiang, Jingyuan Luo, Hetong Gao, Wing Lam Wendy To, Lin Zhu, Chengyuan Lin, Chunsu Yuan, Haitao Xiao, Lixiang Zhai, Zhaoxiang Bian
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Pharmacological Research
Subjects:
Functional constipation
CDD-2101
Gut microbiota
Ruminococcus gnavus
Aromatic trace amines
Serotonin
Online Access:http://www.sciencedirect.com/science/article/pii/S104366182500235X
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